Citation: Yu-Heng Ma, Gang Wu, Nan Jiang, Shu-Wang Ge, Qian Zhou, Bai-Wang Sun. Microwave-assisted, facile, rapid and solvent-free one pot two-component synthesis of some special acylals[J]. Chinese Chemical Letters, ;2015, 26(1): 81-84. doi: 10.1016/j.cclet.2014.11.001 shu

Microwave-assisted, facile, rapid and solvent-free one pot two-component synthesis of some special acylals

Yu-Heng Ma ^a ,
Gang Wu ^b ,
Nan Jiang ^c ,
Shu-Wang Ge ^a ,
Qian Zhou ^a ,
Bai-Wang Sun ^a,,

1.
a School of Chemistry and Chemical Engineering, Southeast University, Nanjing 210096, China;
2.
b Nanjing SimnovTecPharmaceuticals, Nanjing 210096, China;
3.
c School of Pharmacy, Nanjing Medical University, Nanjing 210096, China

Corresponding author: Bai-Wang Sun,
Received Date: 28 June 2014
Available Online: 22 October 2014

A facile, rapid and solvent-free method for the conversion of acids and dihalomethane to the corresponding methylene diesters (acylals) using microwave as activators or assistor, is reported. This method is particularly powerful for the diesterification of carboxylic acids, which afford methylene diesters in good to excellent yields (up to >99%). When the intermediate is trapped, a "double successive S_N2 reactions" mechanism is proved.
- Double successive S_N2 reactions,
- Acylal,
- Anilines,
- Methylene diester
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