Citation: Shahnaz Rostamizadeh, Masoomeh Nojavan, Reza Aryan. Synthesis of N²-arylaminopyrimidine-5-carbonitrile derivatives via S_NAr amination reaction[J]. Chinese Chemical Letters, ;2015, 26(1): 152-156. doi: 10.1016/j.cclet.2014.10.007 shu

Synthesis of N²-arylaminopyrimidine-5-carbonitrile derivatives via S_NAr amination reaction

a Department of Chemistry, Faculty of Science, K.
a Department of Chemistry, Faculty of Science, K. N. Toosi University of Technology, P.O. Box 15875-4416, Tehran, Iran;
2.
b Department of Chemistry, Faculty of Science, University of Zabol, Zabol, Iran

Corresponding author: Shahnaz Rostamizadeh,
Received Date: 24 April 2014
Available Online: 31 July 2014

An efficient and high-yielding synthesis of N²-arylaminopyrimidine-5-carbonitrile derivatives starting from arylamines and 2-methylthio-pyrimidine-5-carbonitrile derivatives has been developed in the presence of cesium carbonate as basic reagent. This new protocol showed high chemical tolerance for a range of functional groups, and only the methylthio substituent on C2 of the pyrimidine ring was replaced with arylamine derivatives under the reaction conditions.
- N²-Arylaminopyrimidine-5-carbonitrile,
- derivatives,
- Pyrimidine-5-carbonitrile derivatives,
- C-N bond formation,
- S_NAr mechanism
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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

Synthesis of N2-arylaminopyrimidine-5-carbonitrile derivatives via SNAr amination reaction

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通讯作者: 陈斌, bchen63@163.com

Synthesis of N²-arylaminopyrimidine-5-carbonitrile derivatives via S_NAr amination reaction