Citation: Chun Liu, Shao-Ke Zhang, Yi-Xia Zhang, Zi-Lin Jin. Arylation of pyridine N-oxides via a ligand-free Suzuki reaction in water[J]. Chinese Chemical Letters, ;2015, 26(1): 55-57. doi: 10.1016/j.cclet.2014.09.019 shu

Arylation of pyridine N-oxides via a ligand-free Suzuki reaction in water

1.
State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China

Corresponding author: Chun Liu,
Received Date: 22 May 2014
Available Online: 4 September 2014
Fund Project: The authors thank the financial support from the National Natural Science Foundation of China (No. 21276043). (No. 21276043)

Wereport a practical and highly efficient protocol for the arylation of pyridine N-oxides with arylboronic acid through palladium-catalyzed Suzuki reaction in water. This ligand-free Suzuki reaction is performed in the presence of diisopropylamine and gives 2- or 3-arylated pyridyl N-oxide derivatives in good to excellent yields within 1 h.
- Pyridine N-oxides,
- Arylation,
- Palladium,
- Suzuki reaction,
- Water
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沈阳化工大学材料科学与工程学院沈阳 110142