Citation: Min-Ming Zou, Feng-Juan Zhu, Xue Tian, Li-Ping Ren, Xu-Sheng Shao, Zhong Li. A novel and facile synthesis of 2-oxo-1,2-dihydropyridine-fused 1,3-diazaheterocycles via heterocyclic keteneaminalsandKonevenagel adducts formed by phthalic anhydride and ethyl cyanacetate[J]. Chinese Chemical Letters, ;2014, 25(12): 1515-1519. doi: 10.1016/j.cclet.2014.09.018 shu

A novel and facile synthesis of 2-oxo-1,2-dihydropyridine-fused 1,3-diazaheterocycles via heterocyclic keteneaminalsandKonevenagel adducts formed by phthalic anhydride and ethyl cyanacetate

1.
Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China

Corresponding author: Xu-Sheng Shao,
Received Date: 5 July 2014
Available Online: 1 September 2014
Fund Project: This work was financial supported by National Natural Science Foundation of China (No. 21372079) (No. 21372079) National High Technology Research Development Program of China (863 Program, No. 2011AA10A207) (863 Program, No. 2011AA10A207) Shanghai Pujiang Program (No. 14PJD012) (No. 14PJD012) Key Projects in the National Science & Technology Pillar Program (No. 2011BAE06B05) (No. 2011BAE06B05)

An efficient synthetic pathway to 2-oxo-1,2-dihydropyridine-fused 1,3-diaza heterocycles from heterocyclic ketene aminals, phathalic anhydride and ethyl cyanacetate was established. This protocol involved aza-ene reaction/imine-enamine tautomerization/enamine-ester exchange/ring-opening reaction sequence.
- Heterocyclic ketene aminals,
- 2-Oxo-1,2-dihydropyridine,
- 1,3-Diazaheterocycle,
- Synthesis
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