Citation: Yue-Xia Zhang, Zhen-Hua Yang, Quan-Xi Zhang, Rui-Jin Li, Hong Geng, Chuan Dong. Chemical compositions and effects on chemiluminescence of AMs in vitro of chalk dusts[J]. Chinese Chemical Letters, ;2015, 26(1): 157-159. doi: 10.1016/j.cclet.2014.08.004 shu

Chemical compositions and effects on chemiluminescence of AMs in vitro of chalk dusts

1.
Institute of Environmental Science, Shanxi University, Taiyuan 030006, China

Corresponding author: Hong Geng, Chuan Dong,
Received Date: 5 May 2014
Available Online: 25 August 2014
Fund Project:

The aim of this study was to investigate the chemical compositions of chalk dust and examine the adverse effects of fine chalk particle matters (PM_2.5) on rat alveolar macrophages (AMs) in vitro. Morphologies and element concentrations of chalk particles were analyzed using quantitative energydispersive electron probe X-ray microanalysis (ED-EPMA). The oxidative response of AMs exposed to chalk PM_2.5 was measured by luminol-dependent chemiluminescence (CL). The results showed that (1) Chalk dust was mainly composed of gypsum (CaSO₄), calcite (CaCO₃)/dolomite (CaMg(CO₃)₂), and organic adhesives; (2) Fine chalk particles induced the AM production of CL, which was inhibited by about 90% by diphenyleneiodonium chloride (DPI). Based on these results, we showed that cytotoxicity of chalk PM_2.5 may be related to the reactive oxygen species (ROS) generation.
- Chemiluminescence,
- Chalk PM_2.5,
- Alveolar macrophages,
- Reactive oxygen species
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沈阳化工大学材料科学与工程学院沈阳 110142