Citation: Yan-Ni Sun, Cui-Ling Wang, Ning Zhang, Zheng Wang, Zhu-Lan Liu, Jian-Li Liu. Synthesis of tetrahydro-β-carbolines from phthalic anhydrides and tryptamine[J]. Chinese Chemical Letters, ;2014, 25(11): 1503-1506. doi: 10.1016/j.cclet.2014.06.012 shu

Synthesis of tetrahydro-β-carbolines from phthalic anhydrides and tryptamine

1.
Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Science, Northwest University, Xi'an 710069, China

Corresponding author: Jian-Li Liu,
Received Date: 3 April 2014
Available Online: 29 May 2014
Fund Project: the National Natural Science Foundation of China (Nos. 20872118, 30070905) (No. IRT1174) the Key Lab Fund of Shaanxi Province of China (Nos. 2010JS097, 11JS090, 12JS110) (Nos. 20872118, 30070905)the Foundation of the Education Department of Shaanxi Province (No. 12JK1010). (Nos. 2010JS097, 11JS090, 12JS110)

Tetrahydro-β-carbolines with strictosamide skeleton have been synthesized via intermolecular condensation, selective reduction, and intramolecular cyclization starting from phthalic anhydrides and tryptamine. The reactions are carried out undermild conditions with a wide range of substrates and functional groups.
- Phthalic anhydride,
- Tryptamine,
- Tetrahydro-β-carboline,
- Strictosamide
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