Citation: Gao-Feng Zha, Wei-Yun Xu, Peng Dai, Xiao-Yan Lai, Wei Liu, Yong-Cun Shen. A simple synthetic approach for the transformation of (S)-Ugi’s amine[J]. Chinese Chemical Letters, ;2014, 25(9): 1301-1304. doi: 10.1016/j.cclet.2014.06.009 shu

A simple synthetic approach for the transformation of (S)-Ugi’s amine

1.
Department of Pharmacy, The College of Chemical Engineering, Wuhan University of Technology, Wuhan 430070, China

Corresponding author: Yong-Cun Shen,
Received Date: 8 April 2014
Available Online: 5 June 2014
Fund Project: We are grateful for financial support from the National Natural Science Foundation of China (No. 20972123) (No. 20972123)

A simple synthetic approach for the transformation of (S)-Ugi's amine, another configuration of (R)-Ugi's amine, one of the most widely used intermediate in the preparation of chiral ferrocene-based ligands, has been developed via esterification using anhydride, alkaline hydrolysis and active manganese dioxide oxidation, and the corresponding ferrocenyl ketone was afforded in good yields.
- (S)-Ugi’s amine,
- Transformation,
- Esterification,
- Hydrolysis,
- Oxidation
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