Citation: Hai-Feng Gan, Wei-Wei Cao, Zheng Fang, Xin Li, Shi-Gui Tang, Kai Guo. Efficient synthesis of chromenopyridine and chromene via MCRs[J]. Chinese Chemical Letters, ;2014, 25(10): 1357-1362. doi: 10.1016/j.cclet.2014.05.008 shu

Efficient synthesis of chromenopyridine and chromene via MCRs

Hai-Feng Gan ^a ,
Wei-Wei Cao ^a ,
Zheng Fang ^b ,
Xin Li ^a ,
Shi-Gui Tang ^a ,
Kai Guo ^a,,

1.
a College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, China;
2.
b School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing 211816, China

Corresponding author: Kai Guo,
Received Date: 21 February 2014
Available Online: 24 April 2014
Fund Project: the National High Technology Research and Development Program of China (863 Program, No. 2013AA031901) (863 Program, No. 2012AA02A701)

MCRs for preparation of chromenopyridines under reflux conditions and chromenes at room temperature conditions from different salicylaldehydes, malononitrile and different thiols (mol ratio = 1:2:1) were established. Mechanistic investigation suggests that the MCRs undergo different pathways at different temperatures and catalyzed by different organic bases. The structure of chromenopyridine and chromene are confirmed by crystal X-ray crystallography.
- Multi-component reaction,
- Chromenopyridine,
- Chromene,
- Mechanistic study,
- Reaction condition
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