Citation: Ling Jiang, Bo Wang, Rong-Rong Li, Sa Shen, Hong-Wei Yu, Li-Dan Ye. “Amano” lipase DF-catalyzed efficient synthesis of 2,20-arylmethylene dicyclohexane-1,3-dione derivatives in anhydrous media[J]. Chinese Chemical Letters, ;2014, 25(8): 1190-1192. doi: 10.1016/j.cclet.2014.04.007 shu

“Amano” lipase DF-catalyzed efficient synthesis of 2,20-arylmethylene dicyclohexane-1,3-dione derivatives in anhydrous media

Ling Jiang ^a ,
Bo Wang ^b ,
Rong-Rong Li ^c ,
Sa Shen ^c ,
Hong-Wei Yu ^a ,
Li-Dan Ye ^a,,

1.
a Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310007, China;
2.
b College of Materials and Chemical Engineering, Hainan University, Haikou 570228, China;
3.
c School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, China

Corresponding author: Li-Dan Ye,
Received Date: 30 December 2013
Available Online: 20 March 2014
Fund Project: the National Natural Science Foundation of China (No. 21176215/21176102) (No. R4110092)the Program for Zhejiang leading team of S&T Innovation (No. 2011R50007). (No. 21176215/21176102)

A simple and efficient method was developed for the synthesis of 2,20-arylmethylene dicyclohexane-1,3-dione derivatives via the Knoevenagel-Michael cascade reactions of aromatic aldehydes and 1,3-cyclic diketones catalyzed by "Amano" lipase DF, which expands the application field of enzyme catalytic promiscuity. This protocol provides several advantages over the traditional chemical synthesis, such as simple work-up procedure, high yields (up to 94%) and environmental friendliness.
- “Amano” lipase DF,
- Knoevenagel condensation,
- Michael addition,
- Catalytic promiscuity
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