Citation: Rong-Rong Zhang, Hai-Yan Tian, Yi Wu, Xiao-Hui Sun, Jian-Long Zhang, Zhi-Guo Ma, Ren-Wang Jiang. Isolation and chemotaxonomic signifi cance of stenine-and stemoninine-type alkaloids from the roots of Stemona tuberosa[J]. Chinese Chemical Letters, ;2014, 25(9): 1252-1255. doi: 10.1016/j.cclet.2014.03.051 shu

Isolation and chemotaxonomic signifi cance of stenine-and stemoninine-type alkaloids from the roots of Stemona tuberosa

1.
a Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China;
2.
b Zhongshan Torch Polytechnic, Zhongshan 528436, China;
3.
c Shenzhen Engineering Laboratory of Lingnan Herbal Resource Development and Application, Shenzhen Institute for Drug Control, Shenzhen 518057, China

Corresponding author: Zhi-Guo Ma, Ren-Wang Jiang,
Received Date: 23 January 2014
Available Online: 21 March 2014
Fund Project: Thisworkwas supported by the Fundamental Research Funds for the Central Universities (No. 11612603) (No. 11612603)

One new stenine-type alkaloid, tuberostemonine D (1), together with five known stenine-type alkaloids (2-6) and two known stemoninine-type alkaloids (7 and 8), were isolated from the roots of Stemona tuberosa. Their structureswere elucidated by extensive spectroscopic methods (IR,UV,MS, 1D and 2D NMR), and the structure of 1 was further confirmed by X-ray diffraction analysis. First simultaneous isolation of stenine-and stemoninine-type alkaloids not only added a newchemical type and increased the chemical diversity of Stemona tuberosa, but also provided chemotaxonomic clues for the close relationship between genera Stemona and Stichoneuron, and favored retaining them in the same family.
- Stemona tuberosa,
- Alkaloid,
- Tuberostemonine-type
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沈阳化工大学材料科学与工程学院沈阳 110142