Citation: Kun Fang, Guo-Qiang Dong, Hai Gong, Na Liu, Zhen-Gang Li, Shi-Ping Zhu, Zhen-Yuan Miao, Jian-Zhong Yao, Wan-Nian Zhang, Chun-Quan Sheng. Design, synthesis and biological evaluation of E-ring modifi ed evodiamine derivatives as novel antitumor agents[J]. Chinese Chemical Letters, ;2014, 25(7): 978-982. doi: 10.1016/j.cclet.2014.03.043 shu

Design, synthesis and biological evaluation of E-ring modifi ed evodiamine derivatives as novel antitumor agents

1.
a School of Pharmacy, Second Military Medical University, Shanghai 200433, China;
2.
b Department of Radiation Oncology, Ji'nan Military General Hospital, Jinan 250031, China

Corresponding author: Chun-Quan Sheng,
Received Date: 4 December 2013
Available Online: 7 March 2014
Fund Project: This work was supported by National Natural Science Foundation of China (Nos. 81222044, 81373278) (Nos. 81222044, 81373278) the National Basic Research Program of China (No. 2014CB541800) (No. 11431920402) Shanghai Rising-Star Program (No. 12QH1402600) (No. 2014CB541800) and Shanghai Municipal Health Bureau (No. XYQ2011038). (No. 12QH1402600)

A series of novel E-ring modified evodiamine derivatives were designed and synthesized as antitumor agents. Their capacity to interfere with the catalytic activity of topoisomerase I and II was evaluated by the relaxation assay. In vitro antitumor activity results revealed that compound 12 showed good antitumor activity with a broad spectrum. Its binding modes with topoisomerase I and II were clarified by molecular docking.
- Evodiamine derivatives,
- Topoisomerase I,
- Topoisomerase II,
- Antitumor activity
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沈阳化工大学材料科学与工程学院沈阳 110142