Citation: Sunil U. Tekale, Vijay P. Pagore, Sushama S. Kauthale, Rajendra P. Pawar. La₂O₃/TFE：An efficient system for room temperature synthesis of Hantzsch polyhydroquinolines[J]. Chinese Chemical Letters, ;2014, 25(8): 1149-1152. doi: 10.1016/j.cclet.2014.03.037 shu

La₂O₃/TFE：An efficient system for room temperature synthesis of Hantzsch polyhydroquinolines

1.
a Department of Chemistry, Shri Muktanand College, Gangapur 431109, India;
2.
b Department of Chemistry, Deogiri College, Aurangabad 431005, India

Corresponding author: Rajendra P. Pawar,
Received Date: 12 November 2013
Available Online: 12 March 2014

Lanthanum oxide (La₂O₃) in combination with 2,2,2-trifluoroethanol (TFE) was found to be an efficient system for the one-pot, four-component synthesis of Hantzsch polyhydroquinoline derivatives from aromatic aldehydes, dimedone, ethyl acetoacetate and ammonium acetate at ambient temperature. The catalyst is heterogeneous and reusable, hence can be separated easily and reused. The present method is featured by mild reaction conditions, use of heterogeneous catalyst, non-chromatographic purification, short reaction time and high yields, which make it an attractive route for the synthesis of polyhydroquinolines.
- Hantzsch polyhydroquinolines,
- La₂O₃,
- TFE
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沈阳化工大学材料科学与工程学院沈阳 110142

La2O3/TFE：An efficient system for room temperature synthesis of Hantzsch polyhydroquinolines

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La₂O₃/TFE：An efficient system for room temperature synthesis of Hantzsch polyhydroquinolines