Citation: Ling-Jun Li, Yu-Qin Zhang, Yang Zhang, An-Lian Zhu, Gui-Sheng Zhang. Synthesis of 5-functionalized-1,2,3-triazoles via a one-pot aerobic oxidative coupling reaction of alkynes and azides[J]. Chinese Chemical Letters, ;2014, 25(8): 1161-1164. doi: 10.1016/j.cclet.2014.03.004 shu

Synthesis of 5-functionalized-1,2,3-triazoles via a one-pot aerobic oxidative coupling reaction of alkynes and azides

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School of Chemistry and Chemical Engineering, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Henan Normal University, Xinxiang 453007, China

Corresponding author: Ling-Jun Li, Gui-Sheng Zhang,
Received Date: 19 November 2013
Available Online: 17 February 2014
Fund Project: We are grateful to the NSFC (Nos. 21172058, 20802017) (Nos. 21172058, 20802017) HASTIT (No. 2012HASTIT10) (No. 2012HASTIT10) PCSIRT (No. IRT1061) (No. IRT1061)Key Technologies R & D Program of Henan Province (No. 112102310319) for financial support. (No. 112102310319)

In this paper, an efficient synthesis of 5-alkynyl-1,2,3-triazoles through a one-pot aerobic oxidative coupling reaction of various alkynes and azides has been developed. Further derivatization of 5-alkynyl-1,2,3-triazoles readily yielded 5-carbonyl-1,2,3-triazoles, 5-carboxylic-1,2,3-triazole, 5-hydroxyalkyl-1,2,3-triazoles and 5-quinoxaline-1,2,3-triazole, which provided an entry into structurally diverse 5-functionalized-1,2,3-triazoles.
- Alkyne,
- Azide,
- 1,2,3-Triazole,
- Copper catalysis
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沈阳化工大学材料科学与工程学院沈阳 110142