Citation: Mahdi Parvar, Jalil Mehrzad, Mohammad Javad Chaichi, Saman Hosseinkhani, Hamid Golchoubian. Quenching effect of deferoxamine on free radical-mediated photon production in luminol and ortho-phenanthroline-dependent chemiluminescence[J]. Chinese Chemical Letters, ;2014, 25(4): 630-634. doi: 10.1016/j.cclet.2014.01.022 shu

Quenching effect of deferoxamine on free radical-mediated photon production in luminol and ortho-phenanthroline-dependent chemiluminescence

1.
a Faculty of Chemistry, Mazandaran University, Babolsar 4741695447, Iran;
2.
b Department of Pathobiology, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad 9177948974, Iran;
3.
c Veterinary Biotechnology Research Group, Institute of Biotechnology, Ferdowsi University of Mashhad, Mashhad 9177948974, Iran;
4.
d Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran 14115-175, Iran

Corresponding author: Jalil Mehrzad,
Received Date: 19 July 2013
Available Online: 24 December 2013
Fund Project: The authors gratefully acknowledge the bureau (area) for research and technology of Ferdowsi University of Mashhad and Mazandaran University, Babolsar, Iran. (area)

Removing excessive free radicals (FRs) by a synthetic chemical might give a clue for treatment of many iron-mediated diseases. Deferoxamine (DFO) can be one of the chemicals of choice for the clue. To investigate photoredox properties of DFO, its quenching effect on superoxide radical (O₂^-·), hydrogen peroxide (H₂O₂) and hydroxyl radical (OH^·) was examined using luminol and ortho-phenanthroline (o-phen) chemiluminescence (CL) systems and UV-vis spectrophotometry. Stern-Volmer equation was also used for the CL kinetics. The observed quenching effect of DFO on CL/photon production in luminol and o-phen CL systems strongly confirmed the static arm of quenching properties of DFO on OH^· and H₂O₂, but much less pronounced on O₂^-·; the quenching property wasmaximal when iron was involved in the reaction systems. The Stern-Volmer plots in the designed photochemical reaction systems also confirmed a potent quenching effect of DFO on FR-mediated CL. Our study highlights strong photoreducing and antioxidant properties of DFO with huge quenching capacity on excessive FRs, and thus implies its promising prospects for therapeutic applications.
- Chemiluminescence,
- Deferoxamine,
- Free radicals,
- Photon production,
- Stern-Volmer plot
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