Citation: Yan Liu, Wu Zhong, Song Li. Syntheses and studies of hydantoin derivatives as potential anti-tuberculosis inhibitors[J]. Chinese Chemical Letters, ;2012, 23(2): 133-136. doi: 10.1016/j.cclet.2011.11.017 shu

Syntheses and studies of hydantoin derivatives as potential anti-tuberculosis inhibitors

Yan Liu ^a,b, ,
Wu Zhong ^b ,
Song Li ^b

a School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China;
b Laboratory of Computer-Aided Drug Design & Discovery, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China

Received Date: 28 June 2011

Fund Project: This work was financially supported by the National High Technology Research and Development Program of China (No. 2006AA020601).

A short and efficient synthesis of (Z)-2-substituted-5-(4-((2-substitued-5-oxoimidazolidin-4-ylidene)methyl)benzamido)-benzoic acid derivatives (8a-g) as potential type of FabH inhibitors is described. Their structures were confirmed by MS, NOE and ¹H NMR.
- Tuberculosis,
- Mycobacterium tuberculosis FabH,
- Enzyme inhibitor,
- Synthesis,
- NOE
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