Citation: Majid M. Heravi, Hossein A. Oskooie, Narges Karimi, Hoda Hamidi. KAl(SO₄)₂·12H₂O catalyzed efficient synthesis of 3,4,6-trisubstituted 2-pyridone in water[J]. Chinese Chemical Letters, ;2011, 22(9): 1059-1062. doi: 10.1016/j.cclet.2011.03.012 shu

KAl(SO₄)₂·12H₂O catalyzed efficient synthesis of 3,4,6-trisubstituted 2-pyridone in water

Department of Chemistry, School of Sciences, Alzahra University, Tehran, Iran

Received Date: 15 December 2010

Fund Project: We are grateful to Iran national Science Foundation for partial support of this work.

An efficient green protocol for the preparation 3, 4, 6-trisubstituted 2-pyridone of employing a condensation reaction of cyanoacetamide and acetylacetone in the presence of KAl (SO₄)₂·12H₂O in water has been described. The present procedure offers advantage such as shorter reaction time, simple workup, and excellent yields.
- Water,
- Alum,
- 3,4,6-Trisubstituted 2-pyridone,
- Click reaction
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