Citation: Ge Meng, Yao Wu Sha, Rui Zhang, Nan Bai. Mild synthesis of N'-aryl-N,N-dimethylformamidinium chloride by Vilsmeier-Haack reagent[J]. Chinese Chemical Letters, ;2011, 22(9): 1043-1046. doi: 10.1016/j.cclet.2011.03.009 shu

Mild synthesis of N'-aryl-N,N-dimethylformamidinium chloride by Vilsmeier-Haack reagent

Ge Meng ^a, ,
Yao Wu Sha ^b ,
Rui Zhang ^b ,
Nan Bai ^b

a Faculty of Pharmacy, School of Medicine, Xi'an Jiaotong University, Xi'an 710061, China;
b The Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, China

Received Date: 6 December 2010

Fund Project: The authors are grateful to the Chinese Postdoctoral Science Foundation for financial support (No. 2004036602).

Formamidine derivatives could be used as the building blocks for substituted heterocyclic compounds with various biological activities. N'-Aryl-N, N-dimethylformamidinium chlorides have been synthesized in high yields by reaction of aromatic primary amines with Vilsmeier-Haack reagent at room temperature. The structures of all the new compounds were identified by ESI-MS, IR and NMR spectra. The steric structures of some of these compounds were clarified by X-ray single crystal analysis.
- Vilsmeier-Haack reagent,
- Formamidinium,
- X-ray single crystal
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