Citation: Shao Peng Chen, Yue Sun, Sheng Biao Wan, Tao Jiang. Facile synthesis of a 4-anilinoquinazoline dimer by Suzuki cross-coupling reaction[J]. Chinese Chemical Letters, ;2011, 22(9): 1033-1035. doi: 10.1016/j.cclet.2011.01.013 shu

Facile synthesis of a 4-anilinoquinazoline dimer by Suzuki cross-coupling reaction

Key Laboratory of Marine Drugs, Chinese Ministry of Education, Shandong Provincial Key Laboratory of Glycoscience & Glycotechnology, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China

Received Date: 15 November 2010

Fund Project: We are grateful for the financial support of Key International S&T Cooperation Projects (No.2008DFA31040 and No.2009DFA32080) of Ministry of Science and Technology of the People's Republic of China.We are also grateful to the Shanghai Institute of Materia Medica Chinese Academy of Sciences for the continuous support in doing biological assay.

A novel 4-anilinoquinazoline dimer linked by a carbon-carbon bond in the C-7 position was synthesized via a one step Suzuki cross-coupling reaction. All structures of new compounds were characterized by ¹H NMR, ¹³C NMR, and HRMS. The inhibition rate of the synthetic 4-anilinoquinazoline dimer 8 against epidermal growth factor receptor-tyrosine kinase enzymes (EGFR) in vitro was 44.4% at the concentration of 5.5 μmol/L.
- Quinazoline,
- Suzuki reaction,
- Dimer,
- EGFR,
- Synthesis
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