Citation: Qing Chao Liu, Tian Tian Guo, Zheng Fan, Dong Li, Wen Hong Li. First total synthesis of two new heterocyclic compounds:Bretschneiderazines A and B[J]. Chinese Chemical Letters, ;2011, 22(7): 801-803. doi: 10.1016/j.cclet.2010.11.036 shu

First total synthesis of two new heterocyclic compounds:Bretschneiderazines A and B

a Department of Pharmaceutical Engineering, Northwest University, Xi’an 710069, China;
b Department of Medical Science, Xi’an Creation College, Yanan University, Xi’an 710100, China

Received Date: 8 October 2010

Fund Project: This work was financially supported by the Scientific Research Foundation of Northwest University (No.PR10035).

Facile synthesis of the two new natural heterocyclic compounds bretschneiderazines A (2) and B (3), isolated from an extract of the stems of Bretschneidera sinensis, is reported. We employed the cyclization reaction of benzamide by directed lithiation and sequential treatment with sulfur and phosgene as key steps. All new compounds have been fully characterized by means of IR, ¹H NMR, ¹³C NMR, and HRMS.
- Heterocyclic compounds,
- Bretschneiderazines,
- Directed lithiation,
- Synthesis
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