Citation: Jian Ta Wang, Ying Wang, Ji Quan Zhang, Xing Cui, Yi Zhang, Gao Feng Zhu, Lei Tang. Diclofenac derivatives with insulin-sensitizing activity[J]. Chinese Chemical Letters, ;2011, 22(4): 409-412. doi: 10.1016/j.cclet.2010.11.008 shu

Diclofenac derivatives with insulin-sensitizing activity

School of Pharmacy, Guiyang Medical College, Guiyang 550004, China

Received Date: 15 July 2010

Fund Project: The research work was supported by National Natural Science Foundation (No. 30960462), Guizhou Social Development Scientific Foundation (No. 2008-3039), Governor's Foundation for Excellent Scientific and Educational Talents of Guizhou (No. 2009-81) and Excellent Youth Scientific Talents Foundation of Guizhou (No. 2009-24).

A series of diclofenac derivatives were synthesized. The insulin-sensitizing activity of 28 new compounds was evaluated in 3T3-L1 cells. The compounds 10a and 10f exhibited similar insulin-sensitizing activity with positive drag rosiglitazone.
- Diclofenac derivatives,
- Synthesis,
- Insulin-sensitizing activity
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