Citation: Xia Wu, Jian Lei, Zhen Lei Song. Synthesis of cyclic β-silylenones via oxidative rearrangement of tertiary α-hydroxy allylsilanes with PCC[J]. Chinese Chemical Letters, ;2011, 22(3): 306-309. doi: 10.1016/j.cclet.2010.10.018 shu

Synthesis of cyclic β-silylenones via oxidative rearrangement of tertiary α-hydroxy allylsilanes with PCC

Key Laboratory of Drug-Targeting of Education Ministry and Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China

Received Date: 1 July 2010

Fund Project: This research was supported by the National Natural Science Foundation of China (No. 20802044), and RFDP (No. 200806101091).

An oxidative rearrangement of cyclic tertiary α-hydroxy allylsilanes has been carried out in refluxing ClCH₂CH₂Cl with pyridinium chlorochromate (PCC). The reaction provides a convenient method to synthesize cyclic β-silylenones in modest to excellent yields.
- Pyridinium chlorochromate,
- Oxidative rearrangement,
- Cyclic β-silylenones
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