Citation: Fei Deng, Jin Jian Lu, Hong Ying Liu, Li Ping Lin, Jian Ding, Jin Sheng Zhang. Synthesis and antitumor activity of novel salvicine analogues[J]. Chinese Chemical Letters, ;2011, 22(1): 25-28. doi: 10.1016/j.cclet.2010.07.009 shu

Synthesis and antitumor activity of novel salvicine analogues

a State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China;
b College of Life Sciences, Northwest A & F University, Yangling 712100, China

Received Date: 21 April 2010

Systematic structure modification of the side train of the lead compound saprothoquinone provides a series of salvicine analogues, fifteen of them were first reported. Some compounds were demonstrated potent cytotoxicity against tumor cells with the 50% inhibition concentration in the micromolar range. Furthermore some compounds showed potent topoisomerase Ⅱ inhibitory effects. The preliminary structure-activity relationship of saprorthoquinone analogues was discussed according to their cytotoxicity against three tumor cells.
- Saprorthoquinone,
- Salvicine,
- Antitumor,
- Structural modification
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