Citation: Rahman Hosseinzadeh, Yaghoub Sarrafi, Nora Aghili. An efficient and mild protocol for the synthesis of unsymmetrical ureas in the absence of catalyst and additives[J]. Chinese Chemical Letters, ;2010, 21(10): 1171-1174. doi: 10.1016/j.cclet.2010.06.014 shu

An efficient and mild protocol for the synthesis of unsymmetrical ureas in the absence of catalyst and additives

Department of Organic Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran

Received Date: 24 February 2010

Fund Project: Financial support of this work from the Research Council of the University of Mazandaran is gratefully acknowledged.

A new practical method for the synthesis of unsymmetrical ureas was achieved by reaction of phenylurea with primary and secondary amines under neutral and mild condition in very good yields. The reaction took place in refluxing dioxane and does not require any catalyst or additives.
- Unsymmetrical ureas,
- Phenylurea,
- Amines,
- Uncatalyzed reaction
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