Citation: Pu Yong Zhang, Sheng Biao Wan, Su Mei Ren, Tao Jiang. First total synthesis of marine alkaloid hyrtiosulawesine[J]. Chinese Chemical Letters, ;2010, 21(11): 1307-1309. doi: 10.1016/j.cclet.2010.05.012 shu

First total synthesis of marine alkaloid hyrtiosulawesine

School of Medicine and Pharmacy, Key Laboratory of Marine Drugs, Ministry of Education, Ocean University of China, Qingdao 266003, China

Received Date: 17 March 2010

Fund Project: We are grateful for the financial support of Key International S&T Cooperation Projects of MOST (No.2008DFA31040).

Hyrtiosulawesine was isolated from Indonesian specimens of the marine sponges Hyrtios erectus and H. reticulatu in 2002. We report here the first total synthesis of hyrtiosulawesine using an efficient and convenient synthetic strategy which could be widely used in the synthesis of other β-carboline compounds. All structures of new compounds were confirmed by ¹H NMR, ¹³C NMR and HRMS.
- β-Carboline,
- Hyrtiosulawesine,
- Pictet-Spengler reaction,
- Tryptamine,
- Total synthesis
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