Citation: Hai Xue, Tao Ma, Lin Wang, Gang Liu. A new method for the synthesis of N-substituted pyrroles[J]. Chinese Chemical Letters, ;2010, 21(11): 1291-1294. doi: 10.1016/j.cclet.2010.04.030 shu

A new method for the synthesis of N-substituted pyrroles

Department of Synthetic Medicinal Chemistry, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China

Received Date: 9 March 2010

Fund Project: This research is supported financially by the National Natural Science Foundation of China (No.90713045), the National 863 Program of China (No.2006AA020501) and Basic scientific research foundation of IMM, CAMS (No.2007ZD03).

An unexpected reaction of 10-bromomethyl-12-oxocalanolide A (2) with primary amine was demonstrated and studied. Consequentially, a new method for the preparation of N-substituted pyrroles starting from γ-halo-α, β-unsaturated ketone was presented.
- 12-Oxo-calanolide A,
- Primary amine,
- N-Substituted pyrroles,
- Synthesis
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