Citation: Li Qun Ouyang, Hai Long Wu, Ya Juan Liu, Jian Yue Wang, Yong Jie Yu, Hong Yan Zou, Ru Qin Yu. Simultaneous determination of metronidazole and tinidazole in plasma by using HPLC-DAD coupled with second-order calibration[J]. Chinese Chemical Letters, ;2010, 21(10): 1223-1226. doi: 10.1016/j.cclet.2010.04.016 shu

Simultaneous determination of metronidazole and tinidazole in plasma by using HPLC-DAD coupled with second-order calibration

a State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China;
b Zhoushan Municipal Center for Disease Control & Prevention, Zhoushan 310062, China

Received Date: 18 January 2010

Fund Project: This work was financially supported by The National Natural Science Foundation of China (No.20775025) and The National Basic Research Program (No.2007CB216404) as well as PCSIRT.

A method using HPLC-DAD coupled with second-order calibration was developed to simultaneously determine metronidazole and tinidazole in plasma samples in this paper. The second-order calibration method based on APTLD (alternating penalty trilinear decomposition) algorithm was proposed to analyze the three-way HPLC-DAD data from both standard and prediction samples, which makes it possible that calibration can be performed even in the presence of unknown interferences with a simple and green chromatographic condition and short analysis time. The results showed that good recoveries were obtained although the chromatographic and spectral profiles of the analytes of interest as well as background were partially overlapped with each other in plasma samples.
- HPLC-DAD,
- Second-order calibration,
- Alternating penalty trilinear decomposition (APTLD),
- Metronidazole,
- Tinidazole,
- Plasma
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