Citation: Harish Rajak, Chinmay K. Behera, Rajesh S. Pawar, Pradeep K. Singour, Murli Dhar Kharya. A novel series of 2,5-disubstituted 1,3,4-thiadiazoles as potential anticonvulsant agent[J]. Chinese Chemical Letters, ;2010, 21(10): 1149-1152. doi: 10.1016/j.cclet.2010.04.012 shu

A novel series of 2,5-disubstituted 1,3,4-thiadiazoles as potential anticonvulsant agent

a SLT Institute of Pharmaceutical Sciences, Guru Ghasidas University, Bilaspur-495 009, (C. G.), India;
b VNS Institute of Pharmacy, Neelbud, Bhopal-462 044, (M. P.), India;
c Department of Pharmaceutical Sciences, Dr. H. S. Gour University, Sagar-470 003, (M. P.), India

Received Date: 29 December 2009

In pursuit for better antiepileptic drug and the importance of semicarbazones and 2, 5-disubstituted 1, 3, 4-thiadiazoles as anticonvulsant pharmacophore, a series of novel N-({5-[(6-methyl-1-benzofuran-3-yl) methyl]-1, 3, 4-thiadiazol-2-yl}carba-mothioyl)-2/3/4-substitutedbenzamide were designed, synthesized and evaluated for their anticonvulsant activity. The findings of the present studies confirmed that the pharmacophore model with four binding sites is crucial for anticonvuisant activity. Structure-activity relationships among synthesized compounds were also established.
- 1,3,4-Thiadiazoles,
- Semicarbazones,
- Anticonvulsant activity
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