Citation: Xue Ming Chen, Hui Wei, Lu Yin, Xing Shu Li. A convenient synthesis of quinazoline derivatives via cascade imino-Diels-Alder and oxidation reaction[J]. Chinese Chemical Letters, ;2010, 21(7): 782-786. doi: 10.1016/j.cclet.2010.03.003 shu

A convenient synthesis of quinazoline derivatives via cascade imino-Diels-Alder and oxidation reaction

Xue Ming Chen ^a,b, ,
Hui Wei ^a ,
Lu Yin ^a ,
Xing Shu Li ^a

a School of Pharmaceutical Science, Sun Yat-Sen University, Guangzhou 510006, China;
b National Technical Center, Shenzhen Neptunus Bioengineering Holdings Co., Ltd., Shenzhen 518057, China

Received Date: 15 October 2009

Fund Project: We thank the financial support from National Natural Science Foundation of China (No. 20972198).

Quinazoline derivatives were synthesized from α-iminoesters via a cascade imino-Diels-Alder and then oxidation reaction catalyzed with CuBr₂. This method provided a new strategy for preparing quinazoline derivatives which may be useful in the synthesis of heterocyclic intermediates.
- Quinazolines,
- α-Iminoesters,
- lmino-Diels-Alder reaction,
- CuBr₂
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