Citation: Lu Yin, Xian Jia, Xing Shu Li, Albert S. C. Chan. Simply air:Vanadium-catalyzed oxidative kinetic resolution of methyl o-chloromandelate by ambient air[J]. Chinese Chemical Letters, ;2010, 21(7): 774-777. doi: 10.1016/j.cclet.2010.03.002 shu

Simply air:Vanadium-catalyzed oxidative kinetic resolution of methyl o-chloromandelate by ambient air

a School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China;
b School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China

Received Date: 15 August 2009

Vanadium-catalyzed oxidative kinetic resolution (OKR) of methyl o-chloromandelate 2a, key intermediate of the well-known oral antiplatelet agent (S)-clopidogrel, was achieved by ambient air for the first time. The air oxidation system, which was composed of vanadium and tridentate Schiff base ligands derived from amino alcohols and salicylaldehyde derivatives, afforded an efficient and economic approach to the target intermediate with high enantioselectivities (> 99% ee).
- Ambient air,
- Vanadium-catalyzed,
- OKR,
- Methyl o-chloromandelate,
- Schiff base ligands
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