Citation: Chuan Xia Yin, Tao Yang, Wei Zhang, Xiao Dong Zhou, Kui Jiao. Electrochemical biosensing for dsDNA damage induced by PbSe quantum dots under UV irradiation[J]. Chinese Chemical Letters, ;2010, 21(6): 716-719. doi: 10.1016/j.cclet.2009.12.025 shu

Electrochemical biosensing for dsDNA damage induced by PbSe quantum dots under UV irradiation

Key Laboratory of Eco-chemical Engineering, Ministry of Education, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, China

Received Date: 7 September 2009

Fund Project: This work was supported by the National Natural Science Foundation of China (No. 20635020, No. 20805025, No. 20975057), the Doctoral Foundation of the Ministry of Education of China (No. 20060426001), the Foundation of Qingdao City (No. 09-1-3-25-jch) and the Doctoral Fund of QUST (No. 0022278).

An electrochemical sensor for the detection of the natural double-stranded DNA (dsDNA) damage induced by PbSe quantum dots (QDs) under UV irradiation was developed. The biosensing membranes were prepared by successively assembling 3-mercaptopropionic acid, polycationic poly (diallyldimethyl ammonium) and dsDNA on the surface of the gold electrode. Damage of dsDNA was fulfilled by immersing the sensing membrane electrode in PbSe QDs suspension and illuminating it with an UV lamp. Cyclic voltammetry was utilized to detect dsDNA damage with Co(phen)₃³⁺ as the electroactive probe. The UV irradiation, Pb²⁺ ions liberated from the PbSe QDs under the UV irradiation and the reactive oxygen species (ROS) generated in the presence of the PbSe QDs also under the UV irradiation were the three factors of inducing the dsDNA damage. The synergistic effect of the three factors might dramatically enhance the damage of dsDNA. This electrochemical sensor provided a simple method for detecting DNA damage, and may be used for investigating the DNA damage induced by other QDs.
- PbSe QDs,
- dsDNA damage,
- UV irradiation,
- Co (phen)₃³⁺,
- ROS
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