Two new 19-oxygenated ent-kaurane diterpenoids from Isodon pharicus

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China;
b College of Chemistry and Engineering, Yunnan Normal University, Kunming 650092, China;
c Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China

Received Date: 1 June 2009

Fund Project: This work was supported financially by the NSFC (No. 30772637 to H.-D. Sun), the NSFC-joint Foundation of Yunnan Province (No. U0832602 to H.-D. Sun), the Major State Basic Research Development Program of China (No. 2009CB522303 and 2009CB940900), the Natural Science Foundation of Yunnan Province (No. 2008CD162), and the Key Project of Knowledge Innovation Project of CAS (No. KSCX2-YW-R-25).

Two new 19-oxygenated ent-kaurane diterpenoids, pharicinins D and E (1 and 2), together with an artifact, pharicinin D acetal (3) were isolated from the leaves of Isodon pharicus. Their structures were determined by 1D and 2D NMR spectroscopic analysis. All of them were evaluated for their cytotoxicity.

Two new 19-oxygenated ent-kaurane diterpenoids from Isodon pharicus

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