Citation: Lei Feng, Jian Yuan Hao, Cheng Dong Xiong, Xian Mo Deng. Synthesis of novel biodegradable poly(ethylene glycol) analogue:Water-soluble aliphatic polyester with pendant oligo(ethylene glycol) chains[J]. Chinese Chemical Letters, ;2009, 20(12): 1502-1505. doi: 10.1016/j.cclet.2009.06.013 shu

Synthesis of novel biodegradable poly(ethylene glycol) analogue:Water-soluble aliphatic polyester with pendant oligo(ethylene glycol) chains

a Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, P.O.Box 415, Chengdu 610041, China;
b School of Microeletronics and Solid State Electronics, University of Electronic Science and Technology of China, Chengdu 610054, China;
c Graduate School of Chinese Academy of Sciences, Beijing 100039, China

Received Date: 19 March 2009

Fund Project: This work was supported by the National Natural Sciences Fund of China (No.50603025) and the Opening Project of State Key Laboratory of Polymer Materials Engineering (Sichuan University).

A novel poly(ethylene glycol) (PEG) analogue composed of aliphatic polyester backbone and pendant oligo(ethylene glycol) short chains is reported.The PEG analogue is a copolymer synthesized by ring-opening alternating copolymerization of succinicanhydride with 2-((2-(2-metho xyethoxy)ethoxy)methyl)oxirane.The structure of the copolymer was confirmed by ¹H NMRspectrum.The effects of the monomer feed ratio on the copolymerization were studied and the polymerization mechanism was given.The PEG analogue disclosed is water-soluble and expected to have promising applications in biomedical fields as a substitute of PEG due to the existence of degradable ester bond in the backbone.
- Water-soluble,
- PEG analogue,
- 2-((2-(2-Methoxyethoxy)ethoxy)methyl)oxirane,
- Ring-opening alternating copolymerization,
- Polyester
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