Citation: Xu Qin Li. The simple synthesis of quinazoline-2,4-dione derivatives using Boc strategy[J]. Chinese Chemical Letters, ;2009, 20(10): 1201-1202. doi: 10.1016/j.cclet.2009.05.001 shu

The simple synthesis of quinazoline-2,4-dione derivatives using Boc strategy

Xu Qin Li

School of Applied Science, University of Science and Technology Beijing, Beijing 100083, China

Received Date: 17 March 2009

Fund Project: State Education Ministry (No.11140058).The Project Sponsored by Beijing Nova Program (No.2008B20) and the Scientific Research Foundation for the Returned Overseas Chinese Scholars

Quinazolinediones are particularly attractive pharmacophores because of their wide range of bioactivities.A convenient synthetic pathway to three-substituted quinazoline-2,4-dione derivatives was developed from substituted anthranilamide via carbonylation with Boc anhydride and then cyclization in the presence of the base sodium methoxide.Good to excellent yields have been achieved.
- Quinazolinediones,
- Carbonylation,
- Cyclization,
- Boc strategy
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