Citation: Yu Lu Chen, Yi Bo Nie, Ming Wu Ding. Efficient synthesis of 5,6-dihydrothieno[3',2':4,5] thieno[2,3-d]pyrimidin-4(3H)-ones via an iminophosphorane[J]. Chinese Chemical Letters, ;2009, 20(9): 1055-1058. doi: 10.1016/j.cclet.2009.04.004 shu

Efficient synthesis of 5,6-dihydrothieno[3',2':4,5] thieno[2,3-d]pyrimidin-4(3H)-ones via an iminophosphorane

a Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, Central China Normal University, Wuhan 430079, China;
b Department of Biology, Xianning Vocational and Technical College, Xianning 437100, China

Received Date: 6 January 2009

Fund Project: We gratefully acknowledge financial support of this work by the National Natural Science Foundation of China (No.20772041) and Key Project of Science and Technology of Ministry of Education of China (No.107082).

5,6-Dihydrothieno[3',2':4,5]thieno[2,3-d]pyrimidin-4(3H)-ones 6 were synthesized in yields of 71-87% by a consecutive method, which includes aza-Wittig reaction of iminophosphorane 3 with aromatic isocynate to give carbodiimide 4 and subsequent reaction of 4 with various amines, phenols or alcohols in the presence of catalytic amount of sodium ethoxide or solid potassium carbonate.
- 5,6-Dihydrothieno[3',2':4,5]thieno[2,3-d]pyrimidin-4(3H)-one,
- Iminophosphorane,
- Aza-Wittig reaction,
- Carbodiimide,
- Isocyanate
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