Citation: Xue Hui Zhang, Wu Zhong, Xing Zhou Li, Song Li. A novel synthesis of 5-aryl-3-cyano-2-pyridones by using vinamidinium salts[J]. Chinese Chemical Letters, ;2009, 20(7): 771-774. doi: 10.1016/j.cclet.2009.02.016 shu

A novel synthesis of 5-aryl-3-cyano-2-pyridones by using vinamidinium salts

Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China

Received Date: 15 December 2008

Fund Project: This work was supported by the National Basic Research Program of China (No.2004CB518908) and the National High Technology Research and Development Program of China (No.2006AA020601).

A variety of vinamidinium salts were condensated with cyanoacetamide in refluxing methanol that contained sodium methoxide to produce 5-aryl-3-cyano-2-pyridones in good yield. Simple experimental conditions were used to prepare ten different 5-aryl-3-cyano-2-pyridones, four of which are new compounds.
- 5-Aryl-3-cyano-2-pyridones,
- Vinamidinium salts,
- Cyclization
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