Citation: Juan Shen, Jing Bo Shi, Fei Hu Chen, Yuan Wang, Jing Jing Ruan, Yan Huang. Synthesis and anti-tumor activity of all-trans retinoic acid derivatives[J]. Chinese Chemical Letters, ;2009, 20(7): 809-811. doi: 10.1016/j.cclet.2009.01.041 shu

Synthesis and anti-tumor activity of all-trans retinoic acid derivatives

a School of Pharmacy, Anhui Medical University, Hefei 230032, China;
b Key Laboratory of Gene Resource Utilization for Severe Disease, Antiinflammatory and Immunopharmacology, Ministry of Education and Anhui Province, Anhui Medical University, Hefei 230032, China

Received Date: 12 December 2008

A series of retinoate and retinamide derivatives were designed, synthesized, and their anti-tumor activities were investigated in NB4 by MTT and flow cytometry assays (FCM). All compounds showed cytotoxicity, especially compounds 1a and 1d exhibited a higher cytotoxicity than other derivatives and all-trans retinoic acid (ATRA). Furthermore, compound 1d could induce NB4 cell lines differentiation efficiently.
- All-trans retinoic acid,
- Synthesis,
- Cell differentiation,
- NB4 cell lines
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