Citation: Hua Bing Zhang, Ji Jun Xue, Xiao Long Zhao, De Gang Liu, Ying Li. Synthesis and biological evaluation of novel steroid-linked nitrogen mustards[J]. Chinese Chemical Letters, ;2009, 20(6): 680-683. doi: 10.1016/j.cclet.2009.01.023 shu

Synthesis and biological evaluation of novel steroid-linked nitrogen mustards

State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, PR China

Received Date: 11 November 2008

Fund Project: We are grateful for the financial support of the National Natural Science Foundation of China (No.20672050).

Two novel steroid-linked nitrogen mustard conjugates 1a and 1b were synthesized by using estrogenic acid 4 coupled with aniline mustard 8 and phenol mustard 13 in an esterification or amidation procedure. Preliminary cytotoxic screening on cancer cell lines in vitro showed that, the steroid-ester linked nitrogen mustard conjugate 1a exhibited obvious increasing of activities.
- Steroid,
- Nitrogen mustards,
- Synthesis,
- Biological activity
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