Citation: Jin Cai Lu, Bei Bei Xu, Song Gao, Hiroyuki Kodama. A new superoxide-generation inhibitor from rhizome of Anemone raddeana Regel[J]. Chinese Chemical Letters, ;2009, 20(6): 694-697. doi: 10.1016/j.cclet.2008.12.037 shu

A new superoxide-generation inhibitor from rhizome of Anemone raddeana Regel

a College of Traditional Chinese Medicine, Shenyang Pharmaceutical University, No. 103 Wenhua Road, Shenyang 110016, China;
b Southwest Natural Product Center, Department of Arid Land Studied, University of Arizona, 250 E. Valencia Road, Tucson, AZ 85710, USA;
c Department of Anesthesiology and Critical Care Medicine, Kochi University, Kohasu, Oko-chi, Nankokushi, Kochi 783-8505, Japan

Received Date: 27 September 2008

Fund Project: This project was supported by National Natural Science Foundation of China (No.30500050) and by Natural Science Foundation of Liaoning province of China (No.2050340).

A new triterpenoid saponins, raddeanoside R₁₉ (1) was isolated from the rhizome of Anemone raddeana Regel. The effects of raddeanoside R₁₉ on superoxide generation in human neutrophil were evaluated. The compound suppressed the superoxide generation induced by N-formyl-methionyl-leucyl-phenylalanine (fMLP), phorbol 12-myristate 13-acetate (PMA) and arachidonic acid (AA) in a different concentration-dependent manner.
- Anemone raddeana Regel,
- Raddeanoside R₁₉,
- Superoxide generation-inhibitor
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