Citation: Xue Ming Chen, Xing Shu Li, Albert S. C. Chan. Highly efficient synthesis of β-amino esters via Mannich-type reaction under solvent-free conditions using ZnCl₂ catalyst[J]. Chinese Chemical Letters, ;2009, 20(4): 407-410. doi: 10.1016/j.cclet.2008.12.030 shu

Highly efficient synthesis of β-amino esters via Mannich-type reaction under solvent-free conditions using ZnCl₂ catalyst

School of Pharmaceutical Science, Sun Yat-Sen University, Guangzhou 510006, China

Received Date: 18 September 2008

Fund Project: We thank the financial support form National Natural Science Foundation of China (No. 20472116).

β-Amino esters were synthesized via ZnCl₂-catalyzed Mannich-type reaction of imines and malonate esters under solvent-free conditions in 6 min. The β-amino ester was converted into the corresponding aspartic acid derivatives.
- Amino esters,
- Aspartic acid derivativates,
- Mannich-type reaction,
- Solvent-free,
- Krapcho decarboxylation reaction,
- Zinc chloride
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