Citation: Fei Ma, Gang LÜ, Wei Fen Zhou, Qiu Juan Wang, Yi Hua Zhang, Qi Zheng Yao. Synthesis and biological evaluation of 2,4-diaminopteridine derivatives as nitric oxide synthase inhibitor[J]. Chinese Chemical Letters, ;2009, 20(4): 420-422. doi: 10.1016/j.cclet.2008.12.012 shu

Synthesis and biological evaluation of 2,4-diaminopteridine derivatives as nitric oxide synthase inhibitor

School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China

Received Date: 25 September 2008

A series of novel 2,4-diamino-pteridines (9a-l) were synthesized and evaluated as inhibitors of inducible nitric oxide synthase (iNOS) in vitro. It was found that 9a, 9d, 9e, 9h, 9i and 9l showed potent inhibitory activities similar to that of methotrexate (MTX),while the activities of 9b, 9c, 9f, 9g, 9j and 9k are stronger than MTX.
- Nitric oxide,
- Tetrahydrobiopterin,
- Nitric oxide synthase,
- Synthesis,
- Inhibitive activity
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