Citation: Zhao Hui Wang, Wen Yun Li, Fu Long Li, Lei Zhang, Wei Yi Hua, Jing Cai Cheng, Qi Zheng Yao. Synthesis and antitumor activity of 7-azaindirubin[J]. Chinese Chemical Letters, ;2009, 20(5): 542-544. doi: 10.1016/j.cclet.2008.12.011 shu

Synthesis and antitumor activity of 7-azaindirubin

a Department of Organic Chemistry, China Pharmaceutical University, Nanjing 210009, China;
b School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China;
c Wuxi JC Pharmaceutical Technology Inc., Wuxi 214036, China

Received Date: 15 October 2008

Twenty 7-azaindirubin derivatives were designed and synthesized. Their antitumor activities were evaluated in vitro against DU145 cell line. The pharmacological results showed that most of the prepared compounds displayed the excellent activity.Compound 18 exhibited the most potent antitumor activity among the tested compounds.
- 7-Azaindirubin,
- Synthesis,
- Antitumor activity
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