Citation: Jing Bo Shi, Jing Gao, Ya Ping Wang, Qi Zheng Yao. Synthesis and antiviral activity of 4H-[1,2,5]oxadiazolo [3,4-d]pyrimidine-5,7-dione 1-oxide nucleosides[J]. Chinese Chemical Letters, ;2009, 20(4): 404-406. doi: 10.1016/j.cclet.2008.12.009 shu

Synthesis and antiviral activity of 4H-[1,2,5]oxadiazolo [3,4-d]pyrimidine-5,7-dione 1-oxide nucleosides

a School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China;
b School of Pharmacy, Anhui Medical University, Hefei 230032, China;
c School of Pharmaceutical Science, Jiangsu University, Zhenjiang 212013, China;
d Zhaoke Pharmaceutical Company Limited, Hefei 230088, China

Received Date: 18 September 2008

Fund Project: We are grateful to the National Natural Science Foundation of China (No. 30572240).

A series of 4H-[1,2,5]oxadiazolo[3,4-d]pyrimidine-5,7-dione 1-oxide nucleosides was designed, synthesized and evaluated against vesicular stomatitis virus (VSV) inWish cell. The antiviral activities of all compounds were stronger than those of acyclovir,while their toxicities were similar to those of acyclovir.
- Oxadiazolo[3,
- 4-d]pyrimidine nucleoside,
- Antivirus,
- Synthesis
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