Citation: Li Tian, Jie Song, Jing Wang, Bin Liu. Synthesis and bioactivity of N-cyclopropanecarboxyl-N'-pyridin-2-yl thiourea derivatives and related fused ring compounds[J]. Chinese Chemical Letters, ;2009, 20(3): 288-291. doi: 10.1016/j.cclet.2008.11.027 shu

Synthesis and bioactivity of N-cyclopropanecarboxyl-N'-pyridin-2-yl thiourea derivatives and related fused ring compounds

College of Chemistry and Life, Tianjin Normal University, Tianjin 300387, China

Received Date: 1 September 2008

Cyclopropanecarboxylic acid or 2,2-dimethyl cyclopropanecarboxylic acid was used as a leading compound for its biological activity. Six new N-(substituted) cyclopropanecarboxyl-N'-pyridin-2-yl thioureas were prepared. Compound 5 was obtained by oxidizing cyclization of compound 4 in the presence of bromine in chloroform solution. The structures of 4 and 5 were confirmed by ¹H NMR and elemental analysis. The preliminary biological tests indicate that compound 4b and 4e have excellent herbicidal activity, and compound 4c and 4f have excellent fungicidal activity.
- Cyclopropanecarboxylic acid,
- Heterocycle,
- Thiourea,
- Biological activity,
- Pyridine
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