Citation: Yi Hua Zeng, Guang Dian Han. A new method for introduction ω-side chain of prostanoid using Barton radical reaction[J]. Chinese Chemical Letters, ;2009, 20(3): 253-255. doi: 10.1016/j.cclet.2008.11.026 shu

A new method for introduction ω-side chain of prostanoid using Barton radical reaction

Institute of Materia Medica, Peking Union Medical College, Chinese Academy Medical Sciences, Beijing 100050, China

Received Date: 11 September 2008

Fund Project: We thank the Ministry of Health for the financial support of China (No. 94-2-025). Professor D.H.R. Barton send us the reagent N-hydroxy-2-thiopyridine in 1994.

A new method for introduction ω-side chain of prostanoid was described in this note. Starting from acid chloride (3), via Barton radical reaction, a trans α,β-unsaturated ketone sython was introduced.
- Acid chloride,
- N-Hydroxy-2-thiopyridine,
- Barton ester,
- ω-Side chain of prostanoid
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