Citation: Li Jun Yan, Quan Zhong Liu, Xue Lian Wang. Novel chiral thioureas for highly enantioselective Michael reactions of malonates to nitroalkenes[J]. Chinese Chemical Letters, ;2009, 20(3): 310-313. doi: 10.1016/j.cclet.2008.11.021 shu

Novel chiral thioureas for highly enantioselective Michael reactions of malonates to nitroalkenes

Laboratory of Applied Chemistry and Pollution Control Technology, College of Chemistry and Chemical Engineering, China West Normal University, Nanchong 637002, China

Received Date: 8 September 2008

Fund Project: We are grateful for the financial support from Natural Science Foundation of China (No. 20772097), Sichuan Provincial Science Foundation for Outstanding Youth (No. 05ZQ026-008) and Key Project of the Education Department of Sichuan Province (No. 2006A081).

Highly efficient Michael addition reactions of malonates to nitroalkenes catalyzed by novel chiral thioureas derived from optically pure BINOL and amino acids are reported. Various trans-nitroalkenes reacted with malonates affording the desired products in up to 95% yield with excellent enantioselectivities (up to 97% ee).
- Michael addition,
- Thiourea,
- Enantioselectivities,
- Nitroalkene and malonate
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