Citation: Yan Chun Zhang, Jin Pei Zhou, Xiao Ming Wu, Wei Hong Pan. Synthesis and antitumor activity of nitric oxide releasing derivatives of AT1 antagonist[J]. Chinese Chemical Letters, ;2009, 20(3): 302-305. doi: 10.1016/j.cclet.2008.11.012 shu

Synthesis and antitumor activity of nitric oxide releasing derivatives of AT1 antagonist

Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China

Received Date: 8 September 2008

Fund Project: This research was supported by the National Natural Science Foundation of China (No. 30472083).

A series of novel nitric oxide-donating derivatives (7a-e, 8a-e) were synthesized by coupling furoxan and nitric oxide with irbesartan analogue and their cytotoxicity against BEL7402 cells in vitro were evaluated by MTT method. It was found that 8c exhibits the most cytotoxic activities with IC₅₀ value of 12.5 μmol/L. The hybrids of AT1 antagonist and nitric oxide donor appear to have beneficial effects on antitumor.
- AT1 antagonist,
- Nitric oxide-donating,
- Antitumor,
- Synthesis
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