Citation: Feng Ping Yi, Hai Yang Sun, Xian Hua Pan, Yuan Xu, Ji Zong Li. Synthesis of Fischer indole derivatives using carboxyl-functionalized ionic liquid as an efficient and recyclable catalyst[J]. Chinese Chemical Letters, ;2009, 20(3): 275-278. doi: 10.1016/j.cclet.2008.11.010 shu

Synthesis of Fischer indole derivatives using carboxyl-functionalized ionic liquid as an efficient and recyclable catalyst

a School of Perfume and Aroma Technology, Shanghai Institute of Technology, Shanghai 200235, China;
b College of Food Science & Technology, Shanghai Ocean University, Shanghai 201306, China;
c Shanghai Technological and Industrial Promotion Center of Traditional Chinese Medicine, Shanghai 201203, China

Received Date: 28 August 2008

Fund Project: We gratefully acknowledge the Key Project of Shanghai Educational Committee (No. 06ZZ82).

Fischer indole cyclization of phenylhydrazine and various ketones using carboxyl-functionalized ionic liquid, 1-carboxymethyl-3-methylimidazolium tetrafluoroborate (abbreviated as [cmmim][BF₄]) as catalyst was successfully performed. The yields of the target compounds were 80-92%, the purities were 96-98%. The catalyst could be recovered and reused for at least six times without significant loss in activity.
- Functionalized ionic liquid,
- Catalyst,
- Fischer indole synthesis
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