Citation: E. Rajanarendar, G. Mohan, E. Kalyan Rao, M. Srinivas. Palladium-catalyzed Suzuki-Miyaura cross-coupling reaction of organoboronic acids with N-protected 4-iodophenyl alanine linked isoxazoles[J]. Chinese Chemical Letters, ;2009, 20(1): 1-4. doi: 10.1016/j.cclet.2008.10.022 shu

Palladium-catalyzed Suzuki-Miyaura cross-coupling reaction of organoboronic acids with N-protected 4-iodophenyl alanine linked isoxazoles

Department of Chemistry, Kakatiya University, Warangal 506009, AP, India

Received Date: 10 July 2008

Fund Project: The authors are thankful to Prof. S.SriHari, Head, Department of Chemistry, Kakatiya University,Warangal for the facilities and to the Director, Indian Institute of Chemical Technology, Hyderabad for recording ¹H NMR and Mass spectra.

Suzuki-Miyaura coupling reaction of N-protected 4-iodopheyl alanine isoxazoles with arylboronic acids, catalyzed by palladium, efficiently produce benzyl-N-(4-bipheyl)-2-(3-methyl-5(E)-2-aryl-1-ethenyl-4-isoxazolyl)-amino-2-oxoethyl) carba-mates in good yields. This process is first of its kind to construct carbon-carbon bond formation having biaryl motif on amino acid linked isoxazole moiety.
- Suzuki-Miyaura coupling,
- C-C bond formation,
- Amino acid linked isoxazoles
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