Citation: Kai Bo Zheng, Jun He, Jie Zhang. Synthesis and antitumor activity of N¹-acetylamino-(5-alkyl/aryl-1,3,4-thiadiazole-2-y1)-5-fluorouracil derivatives[J]. Chinese Chemical Letters, ;2008, 19(11): 1281-1284. doi: 10.1016/j.cclet.2008.09.021 shu

Synthesis and antitumor activity of N¹-acetylamino-(5-alkyl/aryl-1,3,4-thiadiazole-2-y1)-5-fluorouracil derivatives

Kai Bo Zheng ^a, ,
Jun He ^a ,
Jie Zhang ^b

a College of Chemistry, Sichuan University, Chengdu 610064, China;
b Department of Nephrology, West China Hospital, Sichuan University, Chengdu 610041, China

Received Date: 21 April 2008

Fund Project: The authors would like to thank the Center of Analysis Testing Sichuan University and Chengdu Institute of Biology Chinese Academy of Sciences for measuring the data of IR,1H NMR,ESI-MS and ESI-HRMS.We also want to thank West China Hospital Sichuan University for testing antitumor activity.

A new series of N¹-acetylamino-(5-alkyl/aryl-1,3,4-thiadiazole-2-y1)-5-fluorouracil derivatives were designed and synthesized.These compounds have not been reported in literature,and their structure chemical were confirmed by IR,¹H NMR and MS (HRMS).The results of antitumor inhibitory activity test showed that some compounds possess more potent antitumor inhibitory activity than 5-fluorouracil.
- Fluorouracil derivatives,
- 1,3,4-Thiadiazole,
- Synthesis,
- Antitumor
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