Citation: Liang You, Wan Nian Zhang, Zhen Yuan Miao, Wei Guo, Xiao Ying Che, Wen Ya Wang, Chun Quan Sheng, Jiang Zhong Yao, Ting Zhou. Synthesis and antitumor activity of novel 10-amino acids ester homocamptothecin analogues[J]. Chinese Chemical Letters, ;2008, 19(7): 811-813. doi: 10.1016/j.cclet.2008.05.011 shu

Synthesis and antitumor activity of novel 10-amino acids ester homocamptothecin analogues

School of Pharmacy, Second Military Medical University, Shanghai 200433, China

Received Date: 7 March 2008

Fund Project: This research was supported by the National Natural Science Foundation of China (No.30371689)Shanghai Major Program Science and Technology Foundation (No.064319009) and Shanghai Leading Academic Discipline Project (No.B906).

Nine racemic homocamptothecin derivatives were synthesized and in vitro antitumor activities were evaluated by standard MTT method.The results showed that some of the compound had higher antitumor activity than iritecan.
- Homocamptotbecin,
- Amino acids ester,
- Antitumor activity,
- Synthesis
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